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In the article the historical periods of accession and development by the Russian State of outlying lands of North-East Asia, administrative and territorial structure and social and economic parameters of the North-East of Russia as a major macroregion are shown. Its social and economic development during the Soviet era (1917-1990) and in the post-Soviet period (2013-1991) are considered more detailed. Regional characteristics that significantly affect the formation of the structure, efficiency and growth in the e...